Today, in line with the evolution of bio-processing techniques to satisfy the concepts on Pharma 4.0, there is heavy emphasis on cell line and expression system improvements. With this background, the demands on bioreactors have become more exacting over recent years, requiring paradigm shifts in manufacturing efficiencies. Continuous optimization, design improvements and characterization of bioreactors are crucial factors placing high demands for innovation in bio-pharmaceutical manufacturing. Therefore, it is inevitable that a focus is placed on new approaches in plant engineering to keep pace with the technological developments of the bio-pharmaceutical industry.
IWT worked to execute an Atorvastatin removal test as the worst-case scenario for a potential new client. The reason for buying a new cleaning system came from failures registered during their own cleaning validation test as a result of the Atorvastatin introduction. In fact, Atorvastatin proved to be resistant to removal due to the high adhesion to the BIN walls, which are used for mixing, with a criticality around the top angles. An integrative test with dihydrate Azithromycin with sugar is requested.
We’ve had some exciting times at STEQ America, recently partnering with even more multinational, pioneering equipment manufacturers to bring you advanced solutions for R&D and manufacturing in pharmaceuticals, biotechnology, and life sciences. Click here to download our new product line flyers and stay current with the innovative technologies you need to be leaders in your industry.
A critical factor for cell cultivation and subsequent success of clinical trials for stem cell therapy is compliance with any specified temperature setpoints, including those with very narrow tolerance ranges. Find out how this European company (also the world’s first private tissue bank) is safely and effectively producing stem cell-based medicines for clinical trials.
Despite the significant safety concerns that come with utilizing them, gas cylinders have traditionally been the most prevalent source of gas supply for laboratory applications. But what’s the better alternative? Find out how labs are experiencing the convenience of gas being produced on demand and at consistently high purity levels of grade 6 or 7.
Steam is the most widely used medium to accomplish sterilization in many of today’s life science industries. As part of that, air removal is a critical factor in assuring temperatures are uniform within the sterilizer chamber. But when it comes to technology – vacuum pump vs. ejector – which one’s best?